All-trans retinoic acid-induced myositis during treatment of acute promyelocytic leukemia

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All-trans-retinoic acid-induced myositis in a child with acute promyelocytic leukemia.

Anthracyclin-based regimens and all-transretinoic acid (ATRA, tretinoin) as differentiating agent are commonly utilized for the treatment of acute promylelocytic leukemia (APL). There are many adverse effects that may be seen during the use of ATRA in patients with APL. Of these, ATRA-induced myositis is rarely described in adults and rare in the children with APL. Herein, we report an 11-year-...

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Acute Promyelocytic Leukemia: All-Trans-Retinoic Acid Era

Acute promyelocytic leukemia (APL) is highly curable with the combination of all retinoic acid (ATRA) and anthracycline based chemotherapy, but the percentage of early deaths remains high. In the present study, we report the clinical, immunophenotypi molecular characteristics and outcome of APL patients diagnosed and treated in various Hospitals of Greece and Cyprus. We describe the data of nin...

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Gene expression profiling during all-trans retinoic acid-induced cell differentiation of acute promyelocytic leukemia cells.

Using cDNA microarrays we determined the gene expression patterns in the human acute promyelocytic leukemia (APL) cell line NB4 during all-trans retinoic acid (ATRA)-induced differentiation. We analyzed the expression of 12,288 genes in the NB4 cells after 12 hours, 24 hours, 48 hours, 72 hours, and 96 hours of ATRA exposure. During this time course, we found 168 up-regulated and more than 179 ...

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Sweet’s syndrome during the treatment of acute promyelocytic leukemia with all-trans retinoic acid

All-trans retinoic acid (ATRA) is the standard induction treatment for acute promyelocytic leukemia (APL). Quite many ATRA-related side effects, including retinoic acid syndrome, were reported. So far, it has rarely been reported that Sweet's syndrome, characterized by fever, neutrophilia, painful erythematous cutaneous plaques, dense dermal infiltrates of mature neutrophils and rapid response ...

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Pseudotumor cerebri induced by all-trans retinoic acid treatment of acute promyelocytic leukemia.

come clinically visible, resulting in the blue appearance of the sclera. We report the treatment of rhegmatogenous retinal detachment in 4 eyes of 3 patients with OI. Scleral buckling surgery, pneumatic retinopexy, and primary vitrectomy are the standards for repair of uncomplicated rhegmatogenous retinal detachments. In patients with OI, however, the thin sclera provides an increased risk of s...

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ژورنال

عنوان ژورنال: Case Reports in Internal Medicine

سال: 2016

ISSN: 2332-7251,2332-7243

DOI: 10.5430/crim.v3n2p46